Camera-ready submissions are open. Deadline: October 25, 2026, 23:59 AoE. Instructions for accepted authors

The First Workshop on

World Models for High-Stakes Health

Reliable Clinical Trial Simulation and Intervention-Aware Reasoning

WMHS @ NeurIPS 2026 December 12, 2026 · Rooms C208–C209 · Atlanta, United States

NeurIPS 2026

Organised by researchers from

Speakers & Panel

Voices across world models, causality, and clinical AI

The workshop brings together researchers and practitioners working across machine learning, clinical development, and trustworthy healthcare AI, with a cross-disciplinary panel on scientific validity, clinical usefulness, evaluation, and responsible deployment.

Invited Speakers

Chris Tomlinson

Chris Tomlinson

Senior Fellow in Clinical Foundation Models

UCL / NHS Foresight

Emre Kıcıman

Emre Kıcıman

Head of Research, Frontier Tuning

Microsoft

Sander Timmer

Sander Timmer

Head of Data Science & AI

Novartis

Nathan Kallus

Nathan Kallus

Director of Machine Learning and Inference Research, Netflix

Associate Professor, Cornell University

Jiajie Zhang

Jiajie Zhang

VP, AI and Machine Learning

GSK

Sandeep Burugupalli

Sandeep Burugupalli

Head of Data Science, BioPharmaceuticals R&D

AstraZeneca

Raja Shankar

Raja Shankar

VP, AI Solutions

IQVIA

Panel Discussion

Jay Nanavati

Jay Nanavati

Head of Advanced AI

IQVIA

Moderator

Carson Kahn

Carson Kahn

Head of Foundation Models & VP, AI Labs

Salesforce

Shameer Khader

Shameer Khader

Global Head — Computational Biology & AI Strategy

Sanofi

Rose Yu

Rose Yu

Assistant Professor of Computer Science

UC San Diego

Monica Agrawal

Monica Agrawal

Assistant Professor of Biostatistics & Bioinformatics

Duke

Andrew Foong

Andrew Foong

AI Scientist & Assistant Professor

Mayo Clinic

About the workshop

Clinical trial simulation as a stress test for world models

Clinical trial simulation is a uniquely demanding and falsifiable testbed for one of the central open problems in machine learning: building reliable world models of complex, partially observed, intervention-rich systems.

This workshop focuses on patient world models — generative and reasoning-capable systems that learn from patient trajectories, trial protocols, interventions, mechanisms of action, and real-world evidence to support clinical trial simulation and decision-making.

Topics of Interest

Where simulation, causality, and clinical evidence meet

We invite work that advances reliable, intervention-aware patient world models — including benchmarks, negative results, position papers, and emerging directions.

Call for Papers

World Models for High-Stakes Health (NeurIPS 2026) invites submissions on architectures, algorithms, theory, empirical studies, benchmarks, demonstrations, and position papers related to patient world models, intervention-aware modelling, clinical trial simulation, virtual populations, and the evaluation and reliable deployment of AI in high-stakes healthcare. Submissions must present original, unpublished work that has not appeared at NeurIPS or other archival machine-learning venues.

Key dates

  • Submission deadline: September 1, 2026, AoE September 15, 2026, AoE.
  • Notification: on or before September 29, 2026, AoE.
  • Camera-ready deadline: October 25, 2026, 23:59 AoE (October 26, 11:59 UTC).
  • Workshop date: December 12, 2026 — Rooms C208–C209, Atlanta.

All deadlines follow the Anywhere on Earth (AoE) timezone.

Submission site

Submissions are managed via OpenReview and remain private during review. All authors should maintain up-to-date OpenReview profiles for conflict-of-interest management and paper matching. Submit your paper at the OpenReview submission portal.

Scope

We welcome contributions across the topics above. Accepted papers are presented as posters, with a subset selected for oral, spotlight, or demonstration talks, and we give a Best Paper Award and a Best Clinical Impact Paper Award for work with particularly strong potential to improve clinical research, healthcare delivery, or patient outcomes. The workshop is in person at NeurIPS 2026 in Atlanta (Rooms C208–C209).

Submission guidelines

Formatting

Submissions must be in English and submitted as a single PDF

  • Full Papers: at most 9 pages of main text.
  • Extended Abstracts: at most 4 pages of main text.
  • Demo Track: working demonstrations of systems and tools for patient modelling, clinical trial simulation, healthcare AI evaluation, or related applications, presented alongside the poster sessions.
  • Position Papers: on validation, governance, regulation, evaluation standards, and the responsible clinical use of AI.

References and appendices do not count toward the page limit, but the main text must be self-contained.

Responsible-use statement

Every submission also includes a short responsible-use statement covering relevant limitations, uncertainty, potential clinical or societal impacts, and suggested mitigations. It is reviewed with the paper, and a missing statement is grounds for desk rejection.

Anonymity during review

The workshop uses double-blind review for initial submissions. Initial submissions must be anonymized, with author names, affiliations, and acknowledgments removed and prior work cited in the third person.

Non-archival policy

The workshop is non-archival. Papers under review elsewhere are welcome, and accepted papers may be published at other venues afterward. Work already published at NeurIPS or other archival machine-learning venues should not be submitted.

Camera-ready instructions for accepted authors

Deadline: October 25, 2026, 23:59 Anywhere on Earth (AoE) — October 26, 2026, 11:59 UTC. Camera-ready revisions are open for accepted papers only.

  1. Sign in to OpenReview, open your existing accepted submission, and select Camera Ready Revision. Upload the final PDF there; do not create a new submission.
  2. Use the original submission template. The final PDF must include author names and affiliations. Check author order, title and abstract in both the PDF and OpenReview; request chair approval before adding or removing authors.
  3. Address reviewer and meta-review feedback, correct errors, and retain the responsible-use statement. Full papers remain limited to 9 pages of main text and extended abstracts to 4 pages; references and appendices are excluded.
  4. WMHS is non-archival. Identify the paper as a WMHS workshop contribution, not a NeurIPS main-track proceedings paper.
  5. By the same deadline, one author per paper should email jay.nanavati@iqvia.com with the paper number, presenting author's name, the exact email used for their NeurIPS profile and registration, and whether they will attend in person in Atlanta on December 12. If registration is pending or attendance is uncertain, state this explicitly. Send these details privately, not in the paper or a public comment.

Final PDFs and metadata will be checked by the program chairs. Please report any difficulty meeting the deadline promptly. Poster specifications, oral presentation timings, and upload instructions will be communicated separately once confirmed.

Contact

Submit your paper

Submissions are managed via OpenReview.

Program

Opening Remarks

Motivation, workshop objectives, and overview of the day.

Invited Talk 1: Patient World Models and Causal Digital Twins

Speaker to be confirmed.

Invited Talk 2: Beyond Imitation: A Structural Approach to Silicon Samples

Nathan Kallus.

Coffee Break

Informal discussion and networking.

Contributed Oral Session 1: Patient World Models and Trial Simulation

Patient world models, virtual trial arms, synthetic controls, EHR foundation models, and trajectory generation.

Invited Talk 3: Medical Foundation Models and Patient Trajectories

Chris Tomlinson.

Lunch Break

Informal networking.

Invited Talk 4: Real-World Evidence, Validation, and Deployment Reliability

Speaker to be confirmed.

Poster Session

Accepted papers and interaction across machine learning, clinical research, causal inference, and industry.

Structured Discussion: What Counts as Validation for a Patient World Model?

Moderated by Emma Slade. Discussion of historical trial emulation, synthetic controls, uncertainty, causal validity, generalisation, and clinical utility.

Coffee Break

Informal discussion and networking.

Contributed Oral Session 2: Reasoning, Evaluation, and Agentic Systems

Reasoning, protocol interpretation, benchmark design, evaluation, and agentic systems for clinical-trial design and evidence generation.

Invited Talk 5: Pharma AI, Clinical Development, and Evidence Generation

Speaker to be confirmed from GSK.

Closing Panel: From Patient World Models to Reliable Clinical Evidence

Moderated by Jay Nanavati. Discussion of trustworthiness, reliability standards, data access, benchmarking, regulatory evidence, and responsible deployment.

Best Paper Awards and Closing Remarks

Presentation of the Best Paper Awards, key conclusions, open research problems, community roadmap, and plans for the post-workshop report.

Organizing Committee

Academia, industry, and clinical AI leadership

Jay Nanavati

Jay Nanavati

Head of Advanced AI

IQVIA

Rahul G. Krishnan

Rahul G. Krishnan

Assistant Professor, CS & Laboratory Medicine & Pathobiology

University of Toronto / Vector Institute

Shalmali Joshi

Shalmali Joshi

Assistant Professor of Biomedical Informatics

Columbia University

Lin Li

Lin Li

Research Associate (PostDoc)

University of Oxford

Katie Link

Katie Link

Digital Health Applied Research

NVIDIA

Emma Slade

Emma Slade

Senior Director of AI/ML

GSK